Patient Resources for Living With Hereditary Angioedema (HAE)

Educational information about HAE, CINRYZE® (C1 esterase inhibitor [human]), and product support services is available to download below.

Mobile Therapy Tracker iPhone App

Mobile Therapy Tracker iPhone App

The HAE Mobile Therapy Tracker is an exciting iPhone application designed to support adults and teenagers with hereditary angioedema (HAE) who use CINRYZE therapy for the routine prevention of their HAE attacks. This convenient tool can help you manage your HAE by creating a personalized calendar designed to help you keep track of your CINRYZE infusions, doctor appointments, and HAE attacks.

Download the app now >

HAE Family Tree Facebook App

HAE Family Tree Facebook App

Build your HAE Family Tree via the interactive app on Facebook. Creating a tree and sharing it with others fosters awareness and encourages your family members to get tested, too.

Create your family tree now ›

HAE Family Health Tree Downloadable Worksheet

HAE Family Health Tree Worksheet

Track your family history of HAE with the HAE Family Health Tree Worksheet. You can input your data on the interactive version, or you can download and print a PDF to share with your doctor and family members.

Download the English version ›

Download the Spanish version ›

HAE Downloadable Doctor Discussion Guide

HAE Doctor Discussion Guide

The Doctor Discussion Guide is designed to encourage discussion between you and your doctor about HAE symptoms and the tests needed to confirm a diagnosis.

Download the guide ›

Digital Hereditary Angioedema Awareness Kit

Digital Awareness Kit

Share the Hereditary Angioedema Awareness Kit—a variety of helpful resources designed to help you communicate information about HAE and the importance of diagnosis and management.

Access the kit ›

Hereditary Angioedema and You Downloadable Pamphlet

Hereditary Angioedema and You

This pamphlet created for you and your loved ones explains what HAE is, symptoms and common triggers, and the benefits of a preventive approach.

Download the English Version ›

Download the Spanish Version ›

Downloadable CINRYZE® (C1 esterase inhibitor [human]) Patient Brochure

Patient Brochure

This patient brochure gives an overview of CINRYZE® (C1 esterase inhibitor [human]) and contains information on how it works to help prevent HAE attacks, how CINRYZE is made, and what to expect from therapy.

Download the English version ›

Download the Spanish version ›

Path to Independence™ Patient Program Brochure

Path to Independence Brochure

This brochure explains the details of complimentary resources available to you through OnePath®, as well as administration training information for eligible patients who are starting self-administration with CINRYZE.

Download now ›

CINRYZE® (C1 esterase inhibitor [human]) Self-Administration Instructions Brochure

Self-Administration Instructions Brochure

This brochure provides step-by-step illustrated instructions on how to self-administer CINRYZE® (C1 esterase inhibitor [human]) therapy. After your healthcare provider has taught you how to self-administer CINRYZE, this guide offers additional support.

Download the English version ›

Download the Spanish version ›

Do not attempt to self-administer unless you have been taught how by your healthcare provider.

Product Support for patients with HAE

Your OnePath® Case Manager will get to know you and your specific needs, and offer resources and product support along the way.

Find out more ›

Administration Options

The Path to Independence™ Program is a complimentary service for eligible patients.

Find out more ›

Indication
CINRYZE® (C1 esterase inhibitor [human]) is an injectable prescription medicine that is used to help prevent swelling and/or painful attacks in teenagers and adults with Hereditary Angioedema (HAE).

Important Safety Information
You should not use CINRYZE if you have had life-threatening immediate hypersensitivity reactions, including anaphylaxis to the product.

Tell your healthcare provider about all of your medical conditions, including if you:

  • have an indwelling catheter/access device in one of your veins.
  • have a history of blood clots, heart disease, or stroke.
  • are taking birth control pills or androgens.
  • are pregnant or planning to become pregnant. It is not known if CINRYZE can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if CINRYZE passes into your milk and if it can harm your baby.

Allergic reactions may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • turning blue (look at lips and gums)
  • fast heartbeat
  • swelling of the face
  • faintness
  • rash
  • hives

Serious blood clots may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms:

  • pain and/or swelling of an arm or leg with warmth over the affected area
  • discoloration of an arm or leg
  • unexplained shortness of breath
  • chest pain or discomfort that worsens on deep breathing
  • unexplained rapid heart rate
  • numbness or weakness on one side of the body

Because CINRYZE is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most common side effects seen with CINRYZE were headache, nausea, rash, and vomiting. These are not all the possible side effects of CINRYZE. Tell your healthcare provider about any side effect that bothers you or that does not go away. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You can also report side effects to Shire Medical Information at 1-866-888-0660.

Please see the Full Prescribing Information.

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