Privacy Policy

This site is owned by Shire. This Online Privacy Policy is designed to tell you about our practices regarding collection, use, and disclosure of information that you may provide via this site. Please be sure to read this entire Online Privacy Policy before using, or submitting information to, this site.

Your Consent

By using a Shire site, you signify your assent to the Shire Online Privacy Policy. If you do not agree to this policy, please do not use our sites. We reserve the right, at our discretion, to change, modify, add, or remove portions of this policy at any time. Please check this page periodically for changes. Your continued use of our sites following the posting of changes to these terms will mean you accept those changes.

About Children

This site is not intended for children under the age of 13. We will not knowingly collect information from site visitors in this age group. We encourage parents to talk to their children about their use of the Internet and the information they disclose to Web sites.

About This Site

In our effort to bring you up-to-date, accurate disease and resource information, we use various expert sources and studies to develop site content. As a result, you may find slight differences in statistics and/or percentages across various articles—because different sources can view data differently. Shire is not engaged in rendering medical or similar professional services or advice via this Web site. If you desire or need such services or advice, you should consult a professional health care provider.

Information We Collect and How We Collect It

Many of the services on our site are offered without our collecting any personally identifiable information from you. You can visit our site and view most of the content anonymously.

The information we gather on our site falls into two categories: (1) personally identifiable information you supply, and (2) aggregate information collected as you navigate through our site.

Personally Identifiable Information Collection

Like many Web sites, this site actively collects information from its visitors both by asking you specific questions and by permitting you to communicate directly with us via email, feedback forms, and/or chat rooms. Some of the information that you submit may be personally identifiable information (that is, information that can be uniquely identified with you, such as your full name, address, email address, phone number, and so on).

Some areas of this site may require you to submit demographic information in order for you to benefit from the specialized features (such as receiving disease-related information, tips/pointers, etc.) or to participate in a particular activity. You will be informed at each information collection point what information is required and what information is optional.

Aggregate Information Collection

As you navigate through a Web site, certain information can be passively collected (that is, gathered without your actively providing the information) using various technologies and means, such as navigational data collection. This site may use Internet Protocol (IP) addresses. An IP Address is a number assigned to your computer by your Internet service provider so you can access the Internet and is generally considered to be non-personally identifiable information, because in most cases an IP address is dynamic (changing each time you connect to the Internet), rather than static (unique to the particular user's computer). We use your IP address to diagnose problems with our server, report aggregate information, determine the fastest route to your computer in connecting to our site, and administer and improve the site.

We also collect information about your use of our site through cookies and similar technology. A "cookie" is a bit of information that a Web site sends to your computer that helps the site remember information about you and your preferences and recognize you as a return visitor to the site. Cookies, by themselves, do not tell us email address or other personally identifiable information.

"Internet tags" (also known as single-pixel GIFs, clear GIFs, invisible GIFs, and 1-by-1 GIFs) are smaller than cookies and tell the Web site server information such as the IP address and browser type related to the visitor's computer. This site may at times use Internet tags.

"Navigational data" ("log files," "server logs," and "clickstream" data) are used for system management, to improve the content of the site, for market research purposes, and to communicate information to visitors. This site may at times use navigational data.

Use and Disclosure of Information

Except as otherwise stated, we may use your information to improve the content of our site, to customize the site to your preferences, to communicate information to you (if you have requested it), for our marketing and research purposes, and for the purposes specified in this Online Privacy Policy. If you provide personally identifiable information to this site, we may combine such information with other actively and passively collected information.

We may disclose your personally identifiable information to our affiliates worldwide that agree to treat it in accordance with this Online Privacy Policy. In addition, we may disclose your personally identifiable information to third parties located in the United States and/or any other country, but only (i) to contractors we use to support our business (e.g., fulfillment services, technical support, delivery services, and financial institutions), in which case we will require such third parties to agree to treat it in accordance with this Online Privacy Policy; (ii) in connection with the sale, assignment, or other transfer of the business of this site to which the information relates, in which case we will require any such buyer to agree to treat it in accordance with this Online Privacy Policy; or (iii) where required by applicable laws, court orders, or government regulations. In addition, we will make full use of all information acquired through this site that is not in personally identifiable form.

Access and Correction

To keep your personally identifiable information accurate, current, and complete, please contact us as specified below. We will take reasonable steps to update or correct personally identifiable information in our possession that you have previously submitted via this site.


We take reasonable steps to protect your personally identifiable information as you transmit your information from your computer to our site and to protect such information from loss, misuse, unauthorized access, disclosure, alteration, or destruction. You should keep in mind that no Internet transmission is ever 100% secure or error-free. In particular, email sent to or from this site may not be secure, and you should therefore take special care in deciding what information you send to us via email. Moreover, where you use passwords, ID numbers, or other special access features on this site, it is your responsibility to safeguard them.

Links to Other Web Sites

This site may contain links or references to Web sites. Please be aware that we do not control other Web sites and that, in any case, this Online Privacy Policy does not apply to those Web sites. We encourage you to read the privacy policy of every Web site you visit.

How to Contact Us

If you have any questions, comments, or concerns about this Online Privacy Policy or about the information practices of this site, or would like to have your information removed from our files, please contact us as follows:

Attn: Online Privacy Policy
300 Shire Way
Lexington, MA 02421

This policy was last revised June 17, 2009.


CINRYZE® (C1 esterase inhibitor [human]) is an injectable prescription medicine that is used to help prevent swelling and/or painful attacks in teenagers and adults with Hereditary Angioedema (HAE).

Important Safety Information
You should not use CINRYZE if you have had life-threatening immediate hypersensitivity reactions, including anaphylaxis to the product.

Tell your healthcare provider about all of your medical conditions, including if you:

  • have an indwelling catheter/access device in one of your veins.
  • have a history of blood clots, heart disease, or stroke.
  • are taking birth control pills or androgens.
  • are pregnant or planning to become pregnant. It is not known if CINRYZE can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if CINRYZE passes into your milk and if it can harm your baby.

Allergic reactions may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • turning blue (look at lips and gums)
  • fast heartbeat
  • swelling of the face
  • faintness
  • rash
  • hives

Serious blood clots may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms:

  • pain and/or swelling of an arm or leg with warmth over the affected area
  • discoloration of an arm or leg
  • unexplained shortness of breath
  • chest pain or discomfort that worsens on deep breathing
  • unexplained rapid heart rate
  • numbness or weakness on one side of the body

Because CINRYZE is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most common side effects seen with CINRYZE were headache, nausea, rash, and vomiting. These are not all the possible side effects of CINRYZE. Tell your healthcare provider about any side effect that bothers you or that does not go away. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088. You can also report side effects to Shire Medical Information at 1-866-888-0660.

Please see the Full Prescribing Information.