What is CINRYZE?

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CINRYZE Dosing and Administration

CINRYZE for prophylaxis can be self-administered by the patient or administered by a caregiver or healthcare provider. Work with each patient to determine the best solution for them.

Patients whose CINRYZE lot number matches one of the eight lot numbers shown in red text below should follow the instructions shown in this booklet.

  • 17F19L370A, 17F24L370A, 17G10L370A, 17G16L370A, 17G21L370A, 17H12L370A, 17G26L370A and 17H22L370A. 

CINRYZE dosing

Pediatric patients (6 to 11 years) Adults and adolescents (≥12 years)
Dose 500 U intravenous
using one 500-unit vial of CINRYZE + one 5 mL vial of Sterile Water for Injection, USP

The dose may be adjusted according to individual response, up to 1,000 U every 3 to 4 days
1,000 U intravenous
using two 500 U vials of CINRYZE + two 5 mL vials of Sterile Water for Injection, USP

Doses up to 2,500 U (not exceeding 100 U/kg) every 3 or 4 days may be considered based on individual patient response

Dosing regimen Single dose can be administered every 3 or 4 days
Infusion rate 5 minutes at 1 mL per minute 10 minutes at 1 mL per minute

The Mix2Vial® transfer device is a needle-free reconstitution and transfer system to facilitate reconstitution and administration.

Would you like a copy of reconstitution and administration instructions for CINRYZE?

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Preparation and handling

  • CINRYZE should not be frozen, and it should be stored in its original carton to protect the active ingredient from light.
  • Once reconstituted, the solution must be used within 3 hours.
  • As supplied, CINRYZE is stable for the period stated on the vial and carton label at 2°C to 25°C (36°F to 77°F); check the expiration date prior to reconstitution.

Keep patients on track

As you work with your HAE patients to create individualized treatment plans, you can help support compliance with CINRYZE. Consider the following approach:

  • Set up a treatment schedule to keep patients on track
  • Empower your patients to take charge by following the infusion schedule you provide
  • Remind patients about the benefits of staying compliant. Even if they are experiencing fewer or no attacks, missing a dose of CINRYZE can result in breakthrough attacks

Help patients stay on track with self-administration training.

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