CINRYZE Resources

Dariela, a real HAE patient, helps prevent her attacks with CINRYZE

Professional and Patient Resources

We've compiled information to help you diagnose and treat hereditary angioedema (HAE), as well as resources you can share with your patients. Additional resources can be found in the Prescribing CINRYZE section.

Materials for healthcare professionals

Empowering HAE Patients Brochure

Empowering Patients brochure

Get a comprehensive overview of HAE, including the physical burden of the disease. You'll also learn how to confirm a diagnosis and start patients on preventative therapy with CINRYZE.

Download the brochure


Encourage Compliance for CINRYZE® Therapy

Encourage Compliance

Compliance is an important part of CINRYZE therapy. Use this guide to help your patients stay on track with prevention.

Download printable sheet


CINRYZE® Mechanism of Action

CINRYZE Mechanism of Action

Learn more about how an HAE attack occurs and how replacement therapy with CINRYZE helps prevent these attacks.

Download printable MOA


CINRYZE® Dosing Flashcard

CINRYZE Dosing Flashcard

Print information on routine prophylactic dosing and reconstitution and keep it on hand.

Download dosing flashcard


CINRYZE Reconstitution and Administration Instructions

If your patient's CINRYZE lot number matches one of the eight lot numbers shown in red text below, please download the first booklet below. For all other patients, please use the second booklet below.


Print instructions for administering CINRYZE®, written for healthcare professionals.

New Instructions for use are available for the following CINRYZE lots:
17F19L370A, 17F24L370A, 17G10L370A, 17G16L370A, 17G21L370A, 17H12L370A, 17G26L370A and 17H22L370A.

Download instructions

Shire advises the patient to receive training from a healthcare professional prior to self-administration.

Print instructions for administering CINRYZE®, written for healthcare professionals.

Print instructions for administering CINRYZE, written for healthcare professionals.

Download instructions

Shire advises the patient to receive training from a healthcare professional prior to self-administration.

Materials for patients and caregivers

HAE Doctor Discussion Guide

HAE Doctor Discussion Guide

Print this guide to encourage discussion with patients and their caregivers about HAE symptoms and the tests needed to confirm an HAE diagnosis.

Download guide


HAE Family Health Tree worksheet

HAE Family Health Tree worksheet

Help patients understand that HAE can affect the whole family by encouraging them to track their family's health history.

Download now


CINRYZE patient brochure

CINRYZE Power of Prevention brochure

This overview of CINRYZE can help patients understand how CINRYZE works, whether a C1-INH preventative therapy might be right for them, and what to expect from therapy.

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Staying on Track With CINRYZE brochure

Staying on Track With CINRYZE brochure

This brochure provides tips and techniques that can help patients stay on track with the treatment schedule that you've created. Give it to patients to help encourage compliance with CINRYZE.

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Path to Independence™ brochure

Path to Independence™ brochure

Share this patient-friendly version of the brochure to provide details about the free services available through the program, including infusion training for eligible patients who are starting self-administration with CINRYZE.

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HAE Attack Plan letter

This letter can be filled out by patients and distributed to appropriate individuals (extended family, bosses, teachers, coaches, etc.) in the event that he or she has an HAE attack.

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CINRYZE Self-Administration Instructions

If your patient's CINRYZE lot number matches one of the eight lot numbers shown in red text below, please download the first booklet below. For all other patients, please use the second booklet below.


CINRYZE® (C1 esterase inhibitor [human]) Self-administration Instructions

New Instructions for use are available for the following CINRYZE lots:
17F19L370A, 17F24L370A, 17G10L370A, 17G16L370A, 17G21L370A, 17H12L370A, 17G26L370A and 17H22L370A.

Download now

Shire advises the patient to receive training from a healthcare professional prior to self-administration.

CINRYZE® (C1 esterase inhibitor [human]) Self-administration Instructions

After you teach patients how to self-administer CINRYZE therapy, share this brochure which features step-by-step illustrated instructions, for additional at-home support.

Download now

Shire advises the patient to receive training from a healthcare professional prior to self-administration.

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