How is CINRYZE Administered?

CINRYZE® (C1 esterase inhibitor [human]) is administered by intravenous (or IV) injection, meaning it is injected into a vein in the arm.

You can choose to have your injection administered by a healthcare provider or caregiver, or a healthcare provider can show you how to give it to yourself. This is called self-administration. A healthcare provider can also train a parent or caregiver to administer CINRYZE to a child.

Do not attempt to self-administer unless you have been taught how by your healthcare provider

CINRYZE is used every 3 or 4 days for prevention of hereditary angioedema (HAE) attacks. It's important that you work closely with your healthcare provider to create a preventive therapy regimen that's right for you or your child.

Path to Independence™ brochure

Would you like to learn how to self-administer CINRYZE? Learn about the Path to Independence™ Program.
Check out self-administration training

Review your self-administration skills

If you have already been trained by a healthcare professional to self-administer CINRYZE, you can watch this video to review the instructions. You can also download self-administration instructions. Talk to your doctor if you think you'd like to be trained in self-administration.

Routine CINRYZE dosing

For a dose of 500 units, one 500-unit vial must be prepared. For a dose of 1,000 units, two 500-unit vials must be prepared. The Mix2Vial transfer device is specifically designed to help make this process easier.

Your healthcare provider may decide that you require higher doses of CINRYZE. You should always follow the specific instructions given by your healthcare provider.

CINRYZE should be prepared and administered at room temperature.

Dosing of CINRYZE
  Adults and teenagers (≥12 years) Children (6 to 11 years)
1,000 U intravenous
For patients who have not responded adequately to 1,000 U, doses up to 2,500 U (not exceeding 100 U/kg) may be considered based on individual response
500 U intravenous
The dose may be adjusted according to individual response, up to 1,000 U
Dosing regimen Administered every 3 or 4 days
Infusion rate 1 mL/min (10 minutes) 1 mL/min (5 minutes)


  • Do not freeze CINRYZE. CINRYZE should be stored in a refrigerator or at room temperature between 36°F to 77°F (2°C to 25°C)
  • CINRYZE should be protected from light
  • Do not use CINRYZE after the expiration date on the vial

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