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If your CINRYZE lot number matches one of the eight lot numbers shown in red text below, follow the instructions shown in this booklet.
If you have already been trained by a healthcare professional to self-administer CINRYZE, you can watch this video to review the instructions. You can also download self-administration instructions. Talk to your doctor if you think you'd like to be trained in self-administration.
For a dose of 500 units, one 500-unit vial must be prepared. For a dose of 1,000 units, two 500-unit vials must be prepared. The Mix2Vial transfer device is specifically designed to help make this process easier.
Your healthcare provider may decide that you require higher doses of CINRYZE. You should always follow the specific instructions given by your healthcare provider.
CINRYZE should be prepared and administered at room temperature.
|Adults and teenagers (≥12 years)||Children (6 to 11 years)|
1,000 U intravenous
For patients who have not responded adequately to 1,000 U, doses up to 2,500 U (not exceeding 100 U/kg) may be considered based on individual response
500 U intravenous
The dose may be adjusted according to individual response, up to 1,000 U
|Dosing regimen||Administered every 3 or 4 days|
|Infusion rate||1 mL/min (10 minutes)||1 mL/min (5 minutes)|
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