How is CINRYZE Administered?

CINRYZE® (C1 esterase inhibitor [human]) is administered by intravenous (or IV) injection, meaning it is injected into a vein in the arm.

You can choose to have your injection administered by a healthcare provider or caregiver, or a healthcare provider can show you how to give it to yourself. This is called self-administration. A healthcare provider can also train a parent or caregiver to administer CINRYZE to a child.

Do not attempt to self-administer unless you have been taught how by your healthcare provider

CINRYZE is used every 3 or 4 days for prevention of hereditary angioedema (HAE) attacks. It's important that you work closely with your healthcare provider to create a preventive therapy regimen that's right for you or your child.

Path to Independence™ brochure

Would you like to learn how to self-administer CINRYZE? Learn about the Path to Independence™ Program.
Check out self-administration training

Review your self-administration skills

If you have already been trained by a healthcare professional to self-administer CINRYZE, you can download self-administration instructions. Talk to your doctor if you think you'd like to be trained in self-administration.

Routine CINRYZE dosing

For a dose of 500 International Units (IU), one 500 International Unit vial must be prepared. For a dose of 1,000 International Units, two 500 IU vials must be prepared. The Mix2Vial transfer device is specifically designed to help make this process easier.

Your healthcare provider may decide that you require higher doses of CINRYZE. You should always follow the specific instructions given by your healthcare provider.

CINRYZE should be prepared and administered at room temperature.

Dosing of CINRYZE
  Adults and teenagers (≥12 years)1 Children (6 to 11 years)1
1,000 IU intravenous
For patients 12 years and older who have not responded adequately to lower doses, the highest dose will be 2000 IU (not to exceed 80 IU/kg). While each dose will contain a 20% increase in C1-INH activity based on the change in reference standard, the new maximum dose (i.e. 2000 IU, corresponding to 2400 U) has been adjusted to not exceed the maximum dose tested in clinical studies (2500 U).
500 IU intravenous
The dose may be adjusted according to individual response, up to 1,000 IU
Dosing regimen Administered every 3 or 4 days
Infusion rate 1 mL/min (10 minutes) 1 mL/min (5 minutes)


  • Do not freeze CINRYZE. CINRYZE should be stored in a refrigerator or at room temperature between 36°F to 77°F (2°C to 25°C)
  • CINRYZE should be protected from light
  • Do not use CINRYZE after the expiration date on the vial

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