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How is CINRYZE Administered?

CINRYZE is administered by intravenous (or IV) injection, meaning it is injected into a vein in your arm. You can choose to have your injection administered by a healthcare provider or caregiver, or a healthcare provider can show you how to give it to yourself. This is called self-administration. A healthcare provider can also train a parent or caregiver to administer CINRYZE to a child.

Do not try to self-administer CINRYZE until a healthcare professional has taught you or a caregiver how.

CINRYZE is used every 3 or 4 days for prevention of hereditary angioedema (HAE) attacks. It's important that you work closely with your healthcare provider to create a prophylactic therapy regimen that's right for you.

Path to Independence™ brochure

Would you like to learn how to self-administer CINRYZE? Learn about the Path to Independence™ Program.
Check out self-administration training

Review your self-administration skills

If your CINRYZE lot number matches one of the eight lot numbers shown in red text below, follow the instructions shown in this booklet.

  • 17F19L370A, 17F24L370A, 17G10L370A, 17G16L370A, 17G21L370A, 17H12L370A, 17G26L370A and 17H22L370A. 

You can also download self-administration instructions. Talk to your doctor if you think you'd like to be trained in self-administration.

Routine CINRYZE dosing

For a dose of 500 units, one 500-unit vial must be prepared. For a dose of 1,000 units, two 500-unit vials must be prepared. The Mix2Vial transfer device is specifically designed to help make this process easier.

Your healthcare provider may decide that you require higher doses of CINRYZE. You should always follow the specific instructions given by your healthcare provider.

CINRYZE should be prepared and administered at room temperature.

Pediatric patients (6 to 11 years) Adult and adolescent patients (≥12 years)
Dose 500 units intravenous
using one 500-unit vial of CINRYZE + one 5 mL vial of Sterile Water for Injection, USP

The dose may be adjusted according to individual response, up to 1,000 units every 3 to 4 days
1,000 units intravenous
using two 500-unit vials of CINRYZE + two 5 mL vials of Sterile Water for Injection, USP

Doses up to 2,500 U (not exceeding 100 U/kg) every 3 to 4 days may be considered on individual patient response
Frequency Single dose can be administered every 3 or 4 days
Duration 5 minutes at 1 mL per minute 10 minutes at 1 mL per minute

Storing and using CINRYZE

  • Store CINRYZE in a refrigerator or at room temperature between 36° and 77° F (2° to 25° C).
  • Do not freeze CINRYZE.
  • Keep CINRYZE in the original carton to protect it from light until ready for use.
  • Do not use CINRYZE after the expiration date on the vial.
  • After dissolving CINRYZE, you can store it at room temperature for up to 3 hours. If you have not used it within 3 hours, throw it away
  • CINRYZE should be administered at room temperature promptly after preparation in the syringe

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