CINRYZE® (C1 esterase inhibitor [human]) is an injectable prescription medicine that is used to help prevent swelling and/or painful attacks in children (6 years of age and older), teenagers and adults with Hereditary Angioedema (HAE).
Below are some of the words and phrases you'll see on this site and hear when people talk about hereditary angioedema, or HAE.
The part of the body between the chest and pelvis that surrounds the stomach, intestines, liver, spleen and pancreas. This is a common location affected during an HAE attack.
A sudden, potentially severe and life-threatening allergic reaction.
Bradykinin is a protein found in the blood. When there is too much bradykinin in the blood, it can result in the swelling experienced during an HAE attack.
C1 esterase inhibitor
C1 esterase inhibitor is a protein found in the blood. When it's at normal levels and working properly, it helps regulate swelling in the body. If there's not enough working C1 esterase inhibitor, your body isn't able to perform this function — and that can put you at risk of an HAE attack.
A protein found in the blood. Measuring C4 levels can help your doctor diagnose and monitor treatment of certain diseases, such as HAE.
Hereditary angioedema (HAE) is a rare genetic disorder. Most cases of HAE are caused by a deficiency in a protein called C1 esterase inhibitor, or the protein they have doesn't work the way it should.
Injected into a vein.
More commonly known as the voice organ, this is the upper part of the airway which enables a person to speak.
Relating to the larynx; commonly associated with the term HAE attack. A laryngeal HAE attack happens when the larynx swells, carrying the potential risk of suffocation.
Action taken to prevent symptoms of a condition or disease.
For CINRYZE, self-administration means you or a loved one injecting CINRYZE into your body.
Beneath the skin. This is one of the primary locations for HAE attacks.
You should not use CINRYZE if you have had life-threatening immediate hypersensitivity reactions, including anaphylaxis, to the product.
Tell your healthcare provider about all of your medical conditions, including if you have an indwelling catheter/access device in one of your veins; have a history of blood clots, heart disease, or stroke; or are taking birth control pills or androgens. Also tell your healthcare provider if you are pregnant or planning to become pregnant, or are breastfeeding or planning to breastfeed. It is not known if CINRYZE can harm your unborn baby, or if CINRYZE passes into your milk and if it can harm your baby.
Allergic reactions may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling of the face, faintness, rash, hives.
Serious blood clots may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid heart rate, numbness or weakness on one side of the body.
Because CINRYZE is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
The most common side effects seen with CINRYZE were headache, nausea, rash, and vomiting. These are not all the possible side effects of CINRYZE. Tell your healthcare provider about any side effect that bothers you or that does not go away. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For additional safety information, please click here for Full Prescribing Information and discuss with your doctor.
You are encouraged to report negative side effects of prescription drugs to the FDA.