About CINRYZE

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What is CINRYZE?

CINRYZE is the first C1 esterase inhibitor (C1-INH) approved by the FDA to help prevent swelling attacks in children (6 years of age and older), teenagers and adults. Available since 2008, CINRYZE has successfully been used to help reduce the frequency, severity, and length of attacks in adolescent and adult patients. In pediatric patients (age 6 to 11), CINRYZE was shown to reduce the number of HAE attacks, lessen the severity of attacks, and reduce the use of acute treatment.

How CINRYZE works

The exact cause for the symptoms experienced by people with hereditary angioedema (HAE) is not known. Most cases of HAE are caused by an insufficient amount of or defective C1 esterase inhibitor, a protein in the blood that helps to prevent swelling experienced during HAE attacks. CINRYZE increases plasma levels of C1 inhibitor activity, thereby preventing the generation of bradykinin and reducing the swelling that causes attacks.

Untreated person with HAE during an attack

Most cases of HAE are caused by an insufficient amount of or defective C1 esterase inhibitor, a protein in the blood that helps to prevent swelling experienced during HAE attacks. The lack of C1-INH may contribute to a cascade of events in the body. This cascade causes another protein, called plasma kallikrein, to trigger the release of a third protein, called bradykinin. Having too much bradykinin causes the blood vessels to release fluid, resulting in localized swelling.

  • Red Blood Cell

  • Blood Vessel Wall

  • Missing/dysfunctional
    C1 esterase inhibitor

  • K (Kallikrein)

  • Tissue Cell

  • Bradykinin

  • Fluid Movement

  • C1 esterase inhibitor

Person with HAE responding to CINRYZE

CINRYZE increases plasma levels of C1 inhibitor activity, thereby preventing the generation of bradykinin and reducing the swelling that causes attacks.

  • Red Blood Cell

  • Blood Vessel Wall

  • Missing/dysfunctional
    C1 esterase inhibitor

  • K (Kallikrein)

  • Tissue Cell

  • Bradykinin

  • Fluid Movement

  • C1 esterase inhibitor

Talk to your doctor about CINRYZE

Are you ready to see if preventative therapy might be right for you? Take the first step by talking with your doctor.

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