Understanding HAE

Scott, a real HAE patient,
helps prevent his
attacks with CINRYZE

What is HAE?

Hereditary angioedema (HAE) is a rare genetic condition. In fact, it's thought that HAE only affects between 1 in 10,000 and 1 in 50,000 people in the world.

HAE can cause attacks of swelling in any part of the body, but the most common locations include the abdomen, face, feet, genitals, hands and throat. The swelling in an HAE attack is sometimes painful. It can happen without warning or an obvious trigger, and it can last for days if untreated.

Remember that an HAE attack that affects the throat is potentially life-threatening because it can interfere with breathing. If you have a throat attack, it's important to seek emergency care as soon as possible.

HAE affects between

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Would you like to learn more about common HAE symptoms?

See symptoms and triggers

Types of HAE

Most people with HAE don't have enough of a protein called C1 esterase inhibitor (C1-INH), or the protein they have doesn't work properly. This deficiency or dysfunction can lead to episodes of swelling.

There are 2 key types of HAE:

Type 1 HAE

Type 1 is the most common and caused by having too little C1-INH circulating in the blood.

Type 2 HAE

Type 2 means a person's body makes enough C1-INH, but the protein doesn't work as it should.

CINRYZE is approved to help prevent HAE attacks in children (6 years of age and older), teenagers and adults.

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