Indication CINRYZE® (C1 esterase inhibitor [human]) is an injectable prescription medicine that is used to help prevent
swelling and/or painful attacks in teenagers and adults with Hereditary Angioedema (HAE).
Jeanie, a real HAE patient,
helps prevent her
attacks with CINRYZE

Adolescents and adults who have commercial insurance may be eligible to receive a OnePath Co-Pay Assistance Card.* This program will help cover the cost of insurance co-pays for CINRYZE at 100%, up to the program maximum, for those who are eligible.
There are no financial requirements and no waiting period to participate in this program.
Contact a OnePath Case Manager at 1-866-888-0660 to find out more.
*Important Note: The OnePath Co-pay Assistance Program (the Program) is not valid for prescriptions eligible to be reimbursed, in whole or in part, by Medicaid, Medicare (including Medicare Part D), or other federal or state programs (including any state prescription drug assistance programs). No claim for reimbursement of the out-of-pocket expense amount covered by the Program shall be submitted to any third-party payer, whether public or private. The Program cannot be combined with any other rebate/coupon, free trial, or similar offer. Co-payment assistance under the Program is not transferable. The Program only applies in the United States and does not apply where prohibited by law, taxed, or restricted. Coverage of certain infusion charges does not apply for patients residing in Massachusetts, Michigan, Minnesota, Rhode Island, and Vermont. Shire Human Genetic Therapies, Inc. reserves the right to rescind, revoke, or amend the Program at any time without notice.
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ExpandClose Important Safety Information
You should not use CINRYZE if you have had life-threatening immediate hypersensitivity reactions, including anaphylaxis to the product.
Tell your healthcare provider about all of your medical conditions, including if you: have an indwelling catheter/access device in one of your veins; have a history of blood clots, heart disease, or stroke; or are taking birth control pills or androgens. Also tell your healthcare provider if you are pregnant or planning to become pregnant, or are breastfeeding or planning to breastfeed. It is not known if CINRYZE can harm your unborn baby, or if CINRYZE passes into your milk and if it can harm your baby.
Allergic reactions may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling of the face, faintness, rash, hives.
Serious blood clots may occur with CINRYZE. Call your healthcare provider or get emergency support services right away if you have any of the following symptoms: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid heart rate, numbness or weakness on one side of the body.
Because CINRYZE is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
The most common side effects seen with CINRYZE were headache, nausea, rash, and vomiting. These are not all the possible side effects of CINRYZE. Tell your healthcare provider about any side effect that bothers you or that does not go away. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see the Full Prescribing Information.
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S10685 08/2016
